Despite the benefits of physical activity (PA), 50.9% of Americans do not meet the American College of Sports Medicine (ACSM) guidelines for exercise. Physical inactivity, low cardiovascular fitness (CVF), obesity and body fat percentage (BF%) are risk factors for increased cardiometabolic morbidity and mortality. Universities create sedentary environments that do not promote PA, thus jeopardizing their employees’ health. PURPOSE: To educate university employees about the health-related benefits of PA and the time frame needed to see changes by meeting the minimum ACSM PA guidelines. METHODS: Female physically inactive university employees were targeted (age 40 ± 11 yrs, body weight 76.9 ± 4.4 kg). Participants underwent basic anthropometric, mean arterial pressure, body composition measurements, and a submaximum oxygen consumption test (using a Bruce protocol) as baseline measurements. Participants were given the ACSM guidelines and instructed to follow them for 12 weeks. No other control was made on participants’ lifestyle factors between the pre- and post-measurements. They were given a Fitbit^© tracker to record and monitor their PA activity levels. This is an ongoing funded project from the Advancement of Interprofessional Collaboration and Education (ADVICE) project and the reported results reflect pre- and post-values from the end of weeks 1 to 4 (N=4). Thus, all measurements were repeated after 4 weeks of the intervention. One-way factorial ANOVA was used to detect changes between Week 1 and Week 4. Significance was set at p < 0.05. All analyses were performed using SPSS^©. RESULTS: BF% was significantly reduced by 38.8% (F_1,5 = 9.943, p = .025, η² = .665). Lean mass was increased by 15.6%, mean arterial pressure was reduced by 9.6% (p > .005), waist circumference was reduced by 5.7% (p > .005), waist hip ratio was reduced by 20.7% (p > .005), minutes of being physically active were increased by 13.7% (p > .005), and predicted maximum oxygen consumption was increased by 4% (p > .005). CONCLUSION: Even though these results represent preliminary data from small sample size the practical significance of this study is that university employees can improve their risks factors for cardiometabolic morbidity and mortality by adhering to the ACSM PA guidelines for even 4 weeks.