Purpose: To evaluate the safety of ultrasound-guided tendon scraping procedures performed at a single center. Methods: This was a single center, retrospective chart review. Following Institutional Review Board approval, all tendon scraping procedures performed by three investigators (JTF, JLS, JS) from January 1, 2011 to September 1, 2018 were identified using the physicians’ procedure logs and by searching the electronic medical record with the term “tendon scraping.” Patient charts were reviewed to search for procedural complications and comorbidities. Results: Fifty-eight tendon scraping procedures performed on 48 people were included in the study. The average age and body mass index were 44.5 (17 to 69) and 28.15 kg/m² (22.33 to 45.36 kg/m²), respectively. There were 29 (60%) males and 19 (40%) females. No complications were reported in the 51 (88%) procedures with follow-up. Procedure location included 25 (43%) patellar tendons, 16 (28%) mid-portion Achilles-tendons, 14 (24%) insertional-Achilles-tendons, and 3 (5%) elbow common extensor tendons. Thirty (52%) procedures were performed on the right and 28 (48%) on the left. Seven (12%) procedures were performed using sterile gloves, sterile ultrasound gel, and sterile ultrasound transducer cover, while 51 (88%) were performed using the same plus a gown, cap, and mask. Comorbidities included hypertension (9 [19%]), hyperlipidemia (7 [15%]), unknown (5 [10%]), hypothyroidism (4 [8%]), migraines (4 [8%]), depression (3 [6%]), anxiety (2 [4%]), fibromyalgia (2 [4%]), obstructive sleep apnea (2 [4%]), tobacco use (1 [2%]), diabetes mellitus (1 [2%]), chronic obstructive pulmonary disease (1 [2%]), non-alcoholic steatohepatitis (1 [2%]), coronary artery disease (1 [2%]), peripheral neuropathy (1 [2%]), undifferentiated connective tissue disorder (1 [2%]), Sjogren’s syndrome (1 [2%]), hyperparathyroidism (1 [2%]), and HIV (1 [2%]). Conclusion: This study suggests that tendon scraping is a safe procedure. While we were unable to perform a sub-analysis to determine if there was an association between comorbid factors and increased complication rates, there were no complications reported in this study despite the presence of multiple comorbidities.